TIL Therapy in Non-small-cell Lung Cancer (NSCLC) Patients

Critères d'exclusion

1. Active central nervous system (CNS) metastases. Patients with stable CNS metastases ≥ 1 month after definitive treatment (eg, surgery and/or radiotherapy) are eligible. 2. Participants with an active second malignancy. 3. Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol, including autoimmune or immunodeficient conditions, significant pulmonary disease, significant cardiac and/or vascular disease per investigator's judgment. 4. Prior immune-related adverse events that would preclude re-challenge with an immune checkpoint inhibitor or immunomodulatory agent per investigator's judgment. 5. Immunosuppressive treatment that would preclude the patient from any of the study therapies per investigator's judgment. 6. Severe active infections or uncontrolled infectious conditions requiring treatment. 7. Any other conditions/diseases, allergies, dysfunctions, and/or findings, that would contraindicate the use of any of the study interventions or therapies. 8. Contraindication for any of the planned measures, interventions and/or treatments. 9. Pregnant or breastfeeding women, or female subject who are not willing to use an acceptable, highly effective method of contraception until the End-of-Study visit. 10. Known hypersensitivity to any of study therapies or drugs used for TIL production. 11. Known human immunodeficiency virus (HIV) infection (or tests positive for HIV 1 or 2 at Screening). 12. Known hepatitis B or hepatitis C infection.