Pharmacoscopy for Patients With Refractory Primary Brain Tumors

Critères d'inclusion

1. Age 18 years or older on day of signing informed consent, female or male. 2. Refractory glioblastoma, isocitrate dehydrogenase (IDH)-mutant astrocytoma or oligodendroglioma, histone-mutant glioma, ependymoma, medulloblastoma, meningioma or other rare primary brain tumor with a histological confirmation according to the WHO classification 2021. Primary tumors can be located at the cerebral or spinal level. Primary brain tumors with metastases outside of the brain may also be considered. 3. Karnofsky performance status of 60 or more 4. Life expectancy \>12 weeks. 5. Limited systemic therapeutic options as per treating physician judgement. The number of previous lines of therapies is not limited. 6. Surgery clinically indicated. A histological confirmation of the diagnosis of a recurrent brain tumor will be required before any treatment can be initiated. 7. Adequate bone marrow, renal and hepatic function 8. Ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and return for the required assessments. 9. Written informed consent for study participation must be signed and dated by the patient and the investigator prior to any study-related intervention.