Valid Biomarkers in Blood to Predict the Response to Therapy in Prostate Cancer Patients

Eligibility criteria

Inclusion Criteria: General inclusion criteria (for entering all groups) • Age ≥ 18 years • Histological diagnosis of prostate adenocarcinoma at different stages of disease (see Section 6.2) for which a treatment is indicated • Written Informed Consent Inclusion criterion only for entering Group 0 • Patients with a known diagnosis of CSPC or CRPC Inclusion criterion only for entering Group 1a • Patients that underwent biopsies for a suspect of PC, but resulted negative for cancer Exclusion Criteria: General exclusion criteria (for entering all groups) • Active infection requiring treatment • Decrease of general condition • Concomitant severe comorbities • Difficult socioeconomic conditions making regular follow up unfeasible. • Need of concomitant steroids at study entry and during the study • Diagnosis of second tumor in the previous 5 years Exclusion criterion only for entering Group 0 • No antibiotic treatments in the previous 2 months before enrollment Exclusion criteria only for entering Group 1 • Previous radical surgery and / or radical radiotherapy • Previous hormonal treatments Exclusion criteria only for entering Group 2 • No antibiotic treatments in the previous 2 months before enrollment (only in patients enrolling also for metagenomics and metabolomics) • Previous hormonal treatments for advanced disease Exclusion criterion only for entering Group 3 • No antibiotic treatments in the previous 2 months before enrollment (only in patients enrolling also for metagenomics and metabolomics analyses)