Imaging Quality and Potential Clinical Relevance of Phase Contrast Mammography In-vivo: a Single-center, Prospective Study

Eligibility criteria

Inclusion Criteria: • Inclusion criteria -Phase 0: • \>18 years • Mastectomy, tumorectomy or biopsy planned • Informed consent of the patient Inclusion criteria -Phase 1: • \>18 years • BI-RADS 5 (highly suggestive of malignancy at ultrasound or mammography) or 6 (known biopsy proven malignancy); • Scheduled for mastectomy or breast conserving surgery with radiotherapy. • Informed consent of the patient Inclusion criteria - Phase 2: • \>40 years • undergoing mammography for screening or diagnostic purpose. • Informed consent of the patient Exclusion Criteria: • Exclusion criteria for all three Phases: • Breast implants. The women will be asked, if they have a breast-implant. • Inability to understand the study procedure due to cognitive or linguistic deficits. Exclusion criteria for patients, participating in Phase 1 and Phase 2: • Pregnancy • Breast-feeding. • Re-staging after neoadjuvant chemotherapy. Patients who participated in prior research projects with ionizing radiation in the past 12 months