A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior Chemotherapy

Exclusion criteria

• EGFR-mutant or ALK-rearranged NSCLC. • Any small cell component • Prior neoadjuvant and/or adjuvant systemic treatment for NSCLC. Note: Previous treatment for another malignancy not excluded as per next criterion (Participating in another interventional clinical trial for NSCLC) is allowed if the below conditions are fulfilled: • Treatment with an approved systemic therapy is completed \>4 weeks before randomisation or • Treatment with systemic biologic therapy is completed \>5 half-lives before randomisation and patient has recovered from any immune-mediated adverse events and endocrinopathies are adequately managed with hormone replacement. • Participating in another interventional clinical trial for NSCLC. • Diagnosis with another malignancy other than NSCLC that is progressing or requires active treatment. Exceptions: • Non-melanoma skin cancer that has undergone potentially curative therapy • In situ cervical carcinoma • Any tumour that has been deemed to be definitively treated, such as definitively treated non-metastatic prostate cancer. • Has any condition requiring ongoing/continuous corticosteroid therapy (\>10 mg prednisone/day or anti-inflammatory equivalent) within 1 week prior to randomisation. Physiologic replacement doses are allowed even if they are \>10 mg of prednisone per day or equivalent, as long as they are not being administered for immunosuppressive intent. Inhaled or topical steroids are permitted, provided that they are not for treatment of an autoimmune disorder. Note: Patients who require a brief course of steroids (ex. 3 days in the week before randomisation) or physiologic replacement are allowed to be included in the study. • Ongoing or recent (within 5 years) evidence of significant autoimmune disease that required treatment with systemic immunosuppressive treatments. The following are not exclusions: vitiligo, childhood asthma that has resolved, endocrinopathies (such as hypothyroidism or type 1 diabetes) that require only hormone replacement, or psoriasis that does not require systemic treatment. • Encephalitis, meningitis, organic brain disease (e.g., Parkinson's disease) or uncontrolled seizures within 1 year prior to randomisation. • Myocardial infarction within 6 months prior to randomisation. • Known history of, or any evidence of, interstitial lung disease or active, non-infectious pneumonitis within 5 years prior to randomisation. • Uncontrolled infection with HIV, hepatitis B, or hepatitis C infection; or the patient has a diagnosis of immunodeficiency. • Patients with known HIV infection who have controlled infection \[undetectable viral load (HIV RNA PCR) and CD4 count above 350 either spontaneously or on a stable antiviral regimen\] are allowed to be included in the study. Patients with controlled HIV infection should be monitored according to local standards. • Patients with hepatitis B (HBsAg+) with controlled infection (serum hepatitis B virus DNA PCR that is below the limit of detection and receiving antiviral therapy for hepatitis B) may be included in the study. Patients with controlled infection must undergo regular monitoring of HBV DNA. Patients must remain on antiviral therapy for at least 6 months after the last dose of cemiplimab. • Patients who are hepatitis C virus antibody positive (HCV Ab+) with controlled infection (undetectable HCV RNA by PCR either spontaneously or in response to a successful prior course of anti-HCV therapy) may be included in the study. • Any infection requiring hospitalisation or treatment with intravenous anti-infectives within 2 weeks before randomisation. • Receipt of a live vaccine within 28 days before randomisation. • Receipt of a COVID-19 vaccination within 1 week before randomisation. • Prior allogeneic stem cell transplantation or received organ transplants at any time, or autologous stem cell transplantation within 12 weeks before randomisation. • Known or suspected hypersensitivity to cemiplimab or its excipients. • Women who are pregnant, planning to become pregnant or are in the period of lactation. • Sexually active men and women of childbearing potential who are not willing to use an effective contraceptive method during the study. • Patients who are, or have an immediate family member who is, a member of the clinical study team, unless prior approval has been obtained from the sponsor (ETOP IBCSG Partners Foundation). • Judgement by the investigator that the patient is unlikely to comply with study procedures, restrictions and requirements.