NCT07100080Recruiting
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Summary
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
Inclusion criteria
• Non-squamous NSCLC, not amenable to treatment in curative intent. • Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation). • Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting. • Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed).
Exclusion criteria
• Inadequate organ function and/or bone marrow reserve. • Leptomeningeal metastases or spinal cord compression. • Poorly controlled systemic medical conditions. • Other protocol-defined inclusion/exclusion criteria apply.
Contacts
The trial team's contact details are shown on request.
See the official trial record- Status
- Recruiting
- Phase
- Phase 2 · Phase 3
- Study type
- Interventional
- Countries
- Switzerland, France, Germany, Italy, United States, Argentina, Belgium, Canada, Chile, China, Colombia, Greece, India, Japan, Mexico, Netherlands, Norway, Poland, Romania, Singapore, South Korea, Spain, Taiwan, Thailand, United Kingdom
- Sponsor
- Bristol-Myers Squibb(Industry)
- Protocol no.
- CA244-0010
- Conditions
- Non-Small Cell Lung Cancer
- Interventions
- Drug
Treatments studied
- Iza-bren
- Carboplatin
- Cisplatin
- Pemetrexed
Locations · 45
- Baden, SwitzerlandKantonsspital BadenRecruiting at this site
- Sankt Gallen, SwitzerlandCantonal Hospital St.GallenRecruiting at this site
- Irvine, United StatesUCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care buildingRecruiting at this site
- Orange, United StatesUniversity of California, Irvine (UCI) Health - UC Irvine Medical CenterRecruiting at this site
- Edwards, United StatesShaw Cancer CenterRecruiting at this site
- Atlanta, United StatesPiedmont HealthcareRecruiting at this site
- Columbus, United StatesJohn B Amos Cancer CenterRecruiting at this site
- Chicago, United StatesRush University Medical CenterRecruiting at this site
- Boston, United StatesDana-Farber Cancer InstituteRecruiting at this site
- St Louis, United StatesWashington University School of MedicineRecruiting at this site
- Reno, United StatesRenown Regional Medical CenterRecruiting at this site
- Mineola, United StatesPerlmutter Cancer Center at NYU Langone Hospital - Long IslandRecruiting at this site
- New York, United StatesNYU Langone HealthRecruiting at this site
- New York, United StatesWeill Cornell Medical CollegeRecruiting at this site
- Rochester, United StatesRochester General Hospital Infectious DiseaseRecruiting at this site
- Cleveland, United StatesUniversity Hospitals Cleveland Medical CenterRecruiting at this site
- Columbus, United StatesThe James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive CRecruiting at this site
- Portland, United StatesProvidence Cancer Institute Franz ClinicRecruiting at this site
- Portland, United StatesProvidence St. Vincent Medical CenterRecruiting at this site
- Portland, United StatesOregon Health and Science UniversityRecruiting at this site
- Philadelphia, United StatesHospital of the University of PennsylvaniaRecruiting at this site
- Pittsburgh, United StatesWest Penn Allegheny HealthRecruiting at this site
- Nashville, United StatesTennessee OncologyRecruiting at this site
- Charlottesville, United StatesUniversity of Virginia Health SystemRecruiting at this site
- Richmond, United StatesVirginia Commonwealth University (Vcu)Recruiting at this site
- Ciudad Autónoma de Buenos Aires, ArgentinaInstituto Alexander FlemingRecruiting at this site
- ABB, ArgentinaHospital Italiano de Buenos AiresRecruiting at this site
- Córdoba, ArgentinaHospital Privado Universitario de CórdobaRecruiting at this site
- Calgary, CanadaArthur J. E. Child Comprehensive Cancer CentreRecruiting at this site
- Toronto, CanadaPrincess Margaret Cancer CentreRecruiting at this site
In total, worldwide, 45 of the 187 sites listed in the registry are recruiting; the other 142 are not currently recruiting.
Site status per the ClinicalTrials.gov registry (last update posted: October 9, 2026).
This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.
+ 15 more locations
Other identifiers
- EU CTR · other identifier
- WHO · other identifier
- CA2440010 · other identifier
See also
Other versions
These results are indicative and do not replace medical advice — discuss them with your doctor.