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NCT07793942Not yet recruiting

A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)

Summary

Researchers are looking for new ways to treat certain types of advanced solid tumors. Solid tumors are cancers mostly in organs and tissues in the body, not in the blood or other fluids. Advanced means the cancer has spread nearby or to other parts in the body and cannot be removed with surgery. In this trial, researchers want to learn if the trial medicine called MK-2010, given alone or with other treatments, can treat advanced solid tumors. MK-2010 is designed to help the immune system fight cancer. The goals of this trial are to learn: * About the safety of MK-2010 as monotherapy and in combinations and if participants tolerate them. Tolerate means participants will receive trial treatment unless they need to stop it due to health problems. * How many participants who receive MK-2010 as monotherapy and in combination respond to treatment. Respond means the cancer gets smaller or goes away.

Inclusion criteria

• Has radiographically measurable disease per protocol • If to receive oral study treatment, has the ability to swallow and retain oral medication and does not have gastrointestinal abnormalities that may alter absorption • Has well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy (ART) if diagnosed with HIV • Has adequate organ function per protocol

Exclusion criteria

• Has a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease if diagnosed with HIV • Has a history of posterior reversible encephalopathy syndrome (PRES) or seizure disorder • Has hepatic encephalopathy, hepatorenal syndrome, or Child-Pugh class B or more severe liver cirrhosis • Has a history of confirmed inflammatory bowel disease • Has a serious active nonhealing wound, ulcer, and/or bone fracture • Has a history of myocarditis or cardiomyopathy • Has a history of or current severe cardiovascular and cerebrovascular diseases • Is currently receiving any anticoagulants • Has a diagnosis of immunodeficiency • Has a known additional malignancy that is progressing or required active treatment within the past 3 years • Has known active central nervous system metastases and/or carcinomatous meningitis • Has active autoimmune disease that required systemic treatment in the past 2 years (hormonal supplementation \[eg, thyroxine, insulin, or physiologic corticosteroid\] is allowed) • Has a history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids or has current pneumonitis/ILD • Has a history of stem cell/solid organ transplant • Has not adequately recovered from major surgery or from central venous access device placement, or has ongoing surgical complications

Contacts

The trial team's contact details are shown on request.

See the official trial record
Status
Not yet recruiting
Phase
Phase 2
Study type
Interventional
Countries
Switzerland, United States
Sponsor
Merck Sharp & Dohme LLC(Industry)
Protocol no.
2010-002
Conditions
Malignant Neoplam, Advanced Solid Tumors
Interventions
Biological, Drug

Treatments studied

  • MK-2010
  • Pembrolizumab
  • 5-Fluorouracil
  • Leucovorin or Levoleucovorin
  • Oxaliplatin
  • Belzutifan
  • Gemcitabine
  • Cisplatin
  • Carboplatin
  • Paclitaxel
  • Nab-paclitaxel
  • Pemetrexed
  • Epinephrine

Locations · 6

  • Sankt Gallen, SwitzerlandCantonal Hospital St.Gallen ( Site 1100)Not yet recruiting at this site
  • Lausanne, SwitzerlandCHUV (centre hospitalier universitaire vaudois) ( Site 1101)Not yet recruiting at this site
  • Belleville, United StatesNew Jersey Cancer Care ( Site 7002)Not yet recruiting at this site
  • East Brunswick, United StatesSTART Astera, LLC ( Site 0220)Not yet recruiting at this site
  • Maumee, United StatesTaylor Cancer Research Center ( Site 9500)Not yet recruiting at this site
  • Eugene, United StatesOncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8001)Not yet recruiting at this site

In total, worldwide, all 6 sites listed in the registry are planned; recruitment has not opened yet.

Site status per the ClinicalTrials.gov registry (last update posted: October 8, 2026).

This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.

Other identifiers

  • MK-2010-002 · other identifier
  • U1111-1325-1503 · other registry
  • 2025-523102-32-00 · other registry
  • 2025 · NIH grant

See also

Other versions

These results are indicative and do not replace medical advice — discuss them with your doctor.