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NCT03790943Recruiting

Cardiac Dysfunction in Childhood Cancer Survivors

Official recordSimplified version

Summary

This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.

Inclusion criteria

This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis. • Registered in the ChCR • Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers • Treated with any chemotherapy and/or chest radiation • Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination • Diagnosed at age ≤ 20 years • ≥ 18 years of age at time of study participation • Resident in Switzerland • Written informed consent

Exclusion criteria

• Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.

Contacts

The trial team's contact details are shown on request.

See the official trial record
Status
Recruiting
Phase
—
Study type
Observational
Countries
Switzerland
Sponsor
University of Bern(Other)
Protocol no.
SCCSS_cardiac_FU
Conditions
Cardiac Dysfunction, Cardiovascular Diseases, Childhood Cancer
Interventions
Diagnostic test

Treatments studied

  • cardiac assessment

Collaborators

University Hospital, Basel, Switzerland, Insel Gruppe AG, University Hospital Bern, Cantonal Hospital of St. Gallen, Luzerner Kantonsspital, University Hospital, Geneva, University Children's Hospital Basel

Locations · 5

  • Basel, SwitzerlandDepartment of Cardiology, University Hospital BaselRecruiting at this site
  • Bern, SwitzerlandDepartment of Cardiology, Inselspital BernRecruiting at this site
  • Geneva, SwitzerlandDepartment of Cardiology, University Hospitals of GenevaRecruiting at this site
  • Lucerne, SwitzerlandDepartment of Cardiology, Lucerne Cantonal HospitalRecruiting at this site
  • Sankt Gallen, SwitzerlandDepartment of Cardiology, Cantonal Hospital of St. GallenRecruiting at this site

In total, worldwide, 5 of the 6 sites listed in the registry are recruiting; the other one is not currently recruiting.

Site status per the ClinicalTrials.gov registry (last update posted: May 29, 2026).

This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.

See also

Other versions

These results are indicative and do not replace medical advice — discuss them with your doctor.