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NCT05427136Recruiting

Early Pulmonary Dysfunction in Childhood Cancer Patients

Official recordSimplified version

Summary

This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.

Inclusion criteria

• at least one of the following cancer treatments: • chest radiation • treatment with any kind of chemotherapy • hematopoietic stem cell transplantation (HSCT) • thoracic surgery • consent for Childhood Cancer Registry (ChCR) registration

Exclusion criteria

• no signed informed consent • Operation outside the chest area as only cancer treatment • Relapsed cancer (patients who develop relapse during the study will not be excluded) • In addition for MRI and lung function tests: • Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy) • Pregnant • MRI measurement not possible without sedation • Metal (e.g. pacemaker) in the body

Contacts

The trial team's contact details are shown on request.

See the official trial record
Status
Recruiting
Phase
—
Study type
Observational
Countries
Switzerland
Sponsor
University Children's Hospital Basel(Other)
Protocol no.
2021-01206; ks22Usemann
Conditions
Pulmonary Dysfunction
Interventions
Diagnostic test, Other

Treatments studied

  • Lung function measurements
  • Breath Analysis
  • Magnetic resonance imaging (MRI)
  • Standardized interview to assess respiratory symptoms
  • Data collection for assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and HSCT
  • Collection of genetic samples

Locations · 5

  • Basel, SwitzerlandUniversity Children's Hospital Basel (UKBB)Recruiting at this site
  • Bern, SwitzerlandUniversitätsklinik für KinderheilkundeRecruiting at this site
  • Geneva, SwitzerlandGeneva University HospitalRecruiting at this site
  • Lausanne, SwitzerlandCentre hospitalier universitaire vaudois LausanneRecruiting at this site
  • Zurich, SwitzerlandUniversitäts-Kinderspital ZürichRecruiting at this site

In total, worldwide, all 5 sites listed in the registry are recruiting.

Site status per the ClinicalTrials.gov registry (last update posted: May 8, 2026).

This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.

See also

Other versions

These results are indicative and do not replace medical advice — discuss them with your doctor.