NCT05641441Recruiting
Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma
Summary
The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated group. The predictive value of radiological tumor characteristics on hearing preservation and vestibular function will be also evaluated. Additionally, the investigators will invite patients with vestibular Schwannoma to fill out questionnaires to assess their quality of life.
Inclusion criteria
• Aged 18 years or above • Patients with unilateral VS treated either with SRS or MRI-based observation strategy, as proposed by the institution's skull base tumor board independently of the study • Patients willing to take part in the study and give their informed consent
Exclusion criteria
• Previous surgical or radiation therapy for VS (including SRS) • Patients diagnosed with neurofibromatosis type II • Preexisting profound hearing loss, with a pure tone average (PTA) \>90 and word recognition score (WRS) \<10%, upon initial assessment • Previous middle ear surgery of the affected ear • Concurrent treatment with other experimental drugs
Contacts
The trial team's contact details are shown on request.
See the official trial record- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Countries
- Switzerland
- Sponsor
- University Hospital, Geneva(Other)
- Protocol no.
- 2022-01257
- Conditions
- Vestibular Schwannoma, Ototoxicity
- Interventions
- Radiation
Treatments studied
- Stereotactic radiosurgery
Locations · 1
- Geneva, SwitzerlandService d'ORL et Chirurge cervico-faciale, Hopitaux Universitaires de GenèveRecruiting at this site
In total, worldwide, the only site listed in the registry is recruiting.
Site status per the ClinicalTrials.gov registry (last update posted: January 13, 2025).
This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.
See also
Other versions
These results are indicative and do not replace medical advice — discuss them with your doctor.