NCT05885048Recruiting
Impact of Gonadotoxic Therapies on Fertility
Summary
The goal of this observational study is to learn how gonadotoxic treatments (chemotherapies, radiotherapies or immunotherapies) affect the fertility status of participants with cancer. The main questions it aims to answer are: * in females, if cancer therapies reduce the Anti-Müllerian hormone (AMH) concentration (ovarian reserve); * in males, if cancer therapies reduce sperm concentration (sperm quality).
Inclusion criteria
• Patients with cancer or with benign reasons undergoing chemotherapy and/or radiotherapy of the pelvis (females) and the testicles (males) and/or immune therapy; • Willing to participate; • Austria: 14-50 years old (adolescents and adults), Germany: 18-50 years old, Switzerland: 14-50 years old (adolescents and adults); • Serum hormone analysis before gonadotoxic therapy (females) or serum hormone analysis and sperm analysis before gonadotoxic therapy (males).
Exclusion criteria
• Missing consent; • Language barrier.
Contacts
The trial team's contact details are shown on request.
See the official trial record- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Countries
- Switzerland
- Sponsor
- Michael von Wolff(Other)
- Protocol no.
- KEK Bern 2022-02284
- Conditions
- Cancer, Fertility Issues, Fertility Preservation, Toxicity Due to Chemotherapy, Toxicity Due to Radiotherapy, Effects of Immunotherapy
- Interventions
- Diagnostic test, Other
Treatments studied
- Blood samples for analysis
- Sperm samples for analysis
- Satisfaction evaluation
- Quality of Life questionnaire
Collaborators
University of Bern
Locations · 1
- Bern, SwitzerlandUniversity Women's Hospital (Inselspital)Recruiting at this site
In total, worldwide, the only site listed in the registry is recruiting.
Site status per the ClinicalTrials.gov registry (last update posted: July 30, 2026).
This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.
Other identifiers
- KLS 5650-08-2022 · other identifier
See also
Other versions
These results are indicative and do not replace medical advice — discuss them with your doctor.