NCT07415668Recruiting
Motor Eloquent Navigated Transcranial Magnetic Stimulation for Radiosurgery Planning
Summary
With this project, the study group wants to investigate whether a postoperative navigated transcranial magnetic stimulation (nTMS) motor map can improve stereotactic radiosurgery (SRS) planning in patients who underwent resection for a brain metastasis near the primary motor cortex. Specifically, the map could allow for more precise location of motor eloquent tissue, thereby minimizing the radiation dose on these areas while preserving high radiation dose on target tissue (i.e. tumor cells).
Inclusion criteria
1. Informed consent 2. Age ≥ 18 years 3. Cerebral metastasis within or adjacent to the primary motor cortex (≤10 mm) 4. Resection of tumor 5. Eligible for and planned to undergo postresection radiosurgery at Inselspital Bern
Exclusion criteria
1. Contraindication to TMS (e.g. Cochlear Implant, other metallic or electrical implants, excluding teeth and post craniotomy, Meniere's disease, pacemaker, deep brain stimulation electrodes, refractory convulsion, symptomatic tinnitus, depression diagnosed by a specialist, psychosis) 2. Prior cerebral radiation therapy within the affected precentral gyrus/affecting the planned SRS plan 3. Planned whole brain radiotherapy 4. Second lesion within 2 cm ipsilateral in the primary motor cortex 5. Infection or difficulties in wound healing within the last two weeks prior inclusion 6. Pregnancy
Contacts
The trial team's contact details are shown on request.
See the official trial record- Status
- Recruiting
- Phase
- No phase (N/A)
- Study type
- Interventional
- Countries
- Switzerland
- Sponsor
- Insel Gruppe AG, University Hospital Bern(Other)
- Protocol no.
- MENTOR
- Conditions
- Metastases to Brain
- Interventions
- Device
Treatments studied
- Navigated Transcranial Magnetic Stimulation (nTMS)
Locations · 1
- Bern, SwitzerlandUniversity Hostpital Bern, Department of Neurosurgery BernRecruiting at this site
In total, worldwide, the only site listed in the registry is recruiting.
Site status per the ClinicalTrials.gov registry (last update posted: August 4, 2026).
This status may have changed and says nothing about your eligibility: before taking any step, check with your oncologist or the site.
See also
Other versions
These results are indicative and do not replace medical advice — discuss them with your doctor.